Resident Evil 3 Remake is filled with things that will make your fight to survive a little easier, such as the Red Dot Sight. You can combine this with your handgun, giving you a nice upgrade, and some increase accuracy while shooting.
To find the Red Dot Sight, you will need to make your way to the pharmacy first to ensure you can get the correct code for a safe.
After Carlos asks you to get to the substation early in the game, and you find the alley that is one fire, turn around and head back the way you came. Some zombies will knock down a fence, and you can take them out with a nearby red barrel.
Head down the steps and into Moon’s Donuts, and be sure to use the Safe Room there. Leave through the back door, and you will find four zombies in the street that you can take out with another red barrel.
Head down the street and you will find the Pharmacy. There is one zombie in the back, so be careful. Take it out, then grab the herb at the counter, and the gunpowder on the shelf, then head to the back of the building and look at the Aqua Cure posted on the wall. There will be three digits on it that are highlighted, and this is the safe combination.
Now, cross the street and go up the fire escape, then in the door. Be careful, as there is another zombie. Take him out and head deeper into the room to find the safe. Use the combination you found on the poster to open it and get the Red Dot Sight.
So far, the combinations we know are any of the following, but it will be random for your playthrough, so it is best to check the poster first, before heading to the safe:
The combinations are always Left, Right, Left on the radial locks on the safes. You can see the exact location of the safe with the Red Dot Sight on the map above.