How to farm Mutagen Sample in Warframe

You’ll need it for some of the weirder weapons.


Mutagen Samples are a valuable resource in Warframe, used in the building of weapons, Sentinels, and some important gear items. They are also combined to make Mutagen Mass.

To get Mutagen Samples, you can farm for them on Eris, or on Orokin Derelict missions. The Orokin Derelict is seen as a better place to farm for them, as Mutagen Samples are a Rare drop on Eris, but only an Uncommon drop on the Derelict, making them easier to find at that location.

Orokin Derelict

To access the Orokin Derelict nodes, you will need to purchase the correct Orokin Derelict Key blueprints from the Market, then build the key in your Foundry. The blueprints are reusable, but the keys are single-use and will be taken from your inventory upon completion of the mission.

The best mission to farm the Mutagen Samples in is the Orokin Derelict Survival. To build the key, you will need to purchase the blueprint for 1500 Credits, then use the following resources:

  • 6500 Credits
  • 5 Nav Coordinates
  • 2500 Nano Spores
  • 750 Salvage
  • 80 Circuits

All the keys have a one minute build time.

To farm as much as possible in Survival missions, find a spot on the map with one entrance, then stay there and all the enemies will come to you. Running a team with a Nekros will allow you to use his Desecrate ability to re-roll the loot tables of dead enemies, increasing the number of resources you will get. You can also run Warframes like Hydroid with Pilfering Swarm, or Khora with Pilfering Stangledome to increase your loot drops. It is a good idea to have one person bring a stealth Frame. They can leave the room you use as a base and get the life support capsules without dragging away any enemies, or just getting destroyed by the number of enemies that will be just outside the door to your safe room.

For these missions, it is also a good idea to farm for as long as possible. Every five-minute rotation will give you an improved percentage chance buff, and some of these affect resource drops.

Mutagen Sample drops are also affected by resource boosters that you can buy from the market place. It can be a great idea to pick up a three-day booster to increase the drop rate of resources, and a three-day booster to double the number of resources that you collect. Dedicate a weekend to doing any farming that you need to do, and you can then enjoy a few months without needing to do much farming at all. Finally, if you have a Smeeta Kavat, its Charm ability will increase the number of Mutagen Samples that you collect.