You can find the Family Matters gig in the Rancho Coronado area of Santo Domingo. For this Cyberpunk 2077 gig, you will need to find out what has happened to a missing member of one of the fixer’s gangs.
The first thing for you to do is to enter the house. You can either go through the main door, or jump up and go through the upstairs windows. If you look around, you will see evidence everywhere that something is amiss.
In a bathroom upstairs is an impressive collection of black-market painkillers and medicines. In one of the bedrooms, you will find a bloodstain on the wall, along with an open medkit that is mostly empty.
Downstairs you will find a safe in the wall near the main computer console. You need to try and get in there, but there is no obvious way to do so. Now it is time to check the basement, but make sure you are at full health with decent close-range weapons before you do. Stalking around in the basement is a Cyberpsycho named Rose. This is Juliet’s sister. It would seem that Rose has gone off the rails, and Juliet was trying to help her. Sadly, Rose has killed Juliet, and you can find her body on the floor of the basement near the Ripperdoc chair.
The easiest way to deal with Rose is with the Cyberware Malfunction Quickhack. She has cyberware that will automatically heal her if her health gets too low, so you want to make sure you can get rid of that advantage. If you have the System Reset quickhack, you can just switch her off completely.
You could also decide to rush in to the basement, search Juliet’s body for the key to the safe, and then rush back out again, so you won’t have to kill Rose. Either way, when you have the key, head back to the ground floor and open the safe, grab the contents, then leave.
You will need to drop off the contents at the drop point close by to wrap up the mission.